Monday, 26th February CD1-MR1 2024

• Unconventional T cell receptor recognition of unconventional ligands - Jamie Rossjohn
• Mitochondrial control of MR1 biology - Gennaro De Libero
• Two-pore channel endosomal calcium signaling enables MR1 presentation of Mycobacterium tuberculosis - Allison E Tammen
• MR1 activates some TCR Vγ9Vδ2 cells in an antigen-dependent manner - J. Pedro Loureiro

• An Inside View of Natural Human CD1 Ligands - Branch Moody
• Recognition of host-derived metabolites through unconventional T cells - Sho Yamasaki
• Molecular mechanisms of γδ T cell receptor recognition of mycobacterial lipids presented by CD1b and CD1c - Tori Tappen
• Atypical mechanisms of lipid antigen presentation to T cells by CD1 antigen-presenting molecules - Adam Shahine
• Identification of human T cells recognizing a mycobacterial adjuvant presented by CD1b - Yuki Sakai
• Metabolomics reveals nucleoside analogs for regulating the mucosal-associated invariant T cell responses - Shouxiong Huang

• Expanding the ImmTAC platform for cancer immunotherapy to unconventional T cell receptors - Mariolina Salio
• Headless self-lipids are recognized by human type I NKT cells (#139) - Ildiko Van Rhijn
• Insights into the molecular recognition mechanism of a headless lipid by type I Natural killer T cell receptor (#131) - Praveena Thirunavukkarasu
• Covalent antigen attachment to MR1 is required for MAIT cell development and expansion (#133) - Charlene Chen
• Interferon signaling drives expression of MR1 (#136) - Megan E Huber
• Characterisation of MR1-reactive T cell responses using newly developed MR1-ligand tetramers (#137) - Michael Souter
• Potent, stable, and functionally distinct chemical tools for studying MR1 and MAIT cell biology (#138) - Jeffrey YW Mak
• Dissecting dendritic cell licensing by MAIT and NKT cells in the priming of unique adaptive immune responses in the lung. (#239) - Hannah Boswell

• Therapeutic potential of targeting CD1a in skin disease - Graham Ogg
• Type 2 NKT cells – new TCRs, new antigens, new diseases. - Catarina Filipa dos Santos Sa e Almeida
• Deleterious role of MAIT cells in virally-induced type 1 diabetes.   - Jeanne Navarre

4:55 - 5:00pm - Introduction to the Cerundolo Lectureship

• CD1 dependence of the human CD4-/CD8- double-negative T cell repertoire. - Annemieke de Jong
• Understanding and optimising the protective role of MAIT cells using mouse models. - Alexandra Corbett

• Establishment of an MR1-presentation reporter screening system to identify MAIT cell modulators - Takuro Matsuoka
• CD1c presentation of a branched ganglioside, GD1a - Guan-Ru Liao
• MAIT cell specialization across paired human tissues - Tobias Kammann
• Development of lumazine analogues as MAIT cell activators - Shinsuke Inuki
• Human neonatal MR1T cells demonstrate diverse TCR usage, pathogen recognition, and functional profiles - Dylan Kain
• An LC-MS optimised liquid extraction method for the detection of MR1-bound ligands - Edward J Mathias
• Development of artificial 5-OP-RU-derived MAIT cell modulators for AICs against microbial infection - Charity CG Ganskow
• CD1c presents the tumour-derived self-lipid antigens in an atypical display of the lipid head group - Thinh-Phat Cao
• The novel role of calcium-sensing synaptotagmins in MR1 antigen presentation of Mycobacterium tuberculosis - Se-Jin (Joyce) Kim
• MR1 senses the natural riboflavin degradation metabolites - Mohamed R. Abdelaal
• MAIT cells exert tissue repair function at steady state in tissues - Marion Salou
• Herpes simplex viruses incapacitate host cell presentation of metabolites by MR1 - Carolyn Samer
• Characterisation of CD1c-restricted T cells in humans - Caroline Soliman
• Mechanisms of self-ganglioside presentation by the antigen presenting molecule CD1b - Yanqiong YC Chen
• Blood Immune Profiling of Heart Transplant Recipients in Children in Australia Showed Major Changes in Proportion of Unconventional T cells Post Heart Transplantation. - Sedi Jalali
• High-dimensional flow cytometry of human peripheral blood mononuclear cells (PBMCs) in cord blood, healthy young adults, and healthy older adults with a focus on chemokine receptor changes - Marziyeh Taheri
• Towards the definition of the MR1 ligandome - Anthony Purcell
• Thymic development of bona fide MAIT cells: Epigenetic landscape leading to the acquisition of MAIT1 versus MAIT17 differentiation program - Anne-laure Le Gac
• Targeted drug delivery through MR1-metabolite presentation - Iris L Batalha
• The role of Notch signaling in the development and differentiation of invariant Natural Killer T (iNKT) cells - Manjula Kamath
• iNKT cells develop through a 4-stage pathway in human thymus     - Naeimeh TAVAKOLINIA
• Macrophages capture and present metabolite antigens in vivo for MAIT cell immunity - Jieru Deng
• Enrichment of CD1-restricted T cells among human CD4-/CD8- double-negative αβ T cells - Reka Chakravarthy
• Modulation of MAIT Cell Activation by Photolumazine V Microheterogeneity - Jason Krawic
• Lipopeptide antigen presentation mediated by classical MHC class I molecules - Minori Asa